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KMID : 0613820140240060686
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Journal of Life Science
2014 Volume.24 No. 6 p.686 ~ p.693
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Expressional Analysis of Two Genes (Got1 and Mat1) Up-regulated by Starvation Stress
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Park Jun-Seok
Kwon Young-Sook
Lee Eun-Ryeong
Kwon Ki-Sang
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Abstract
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Restricted supply of nutrients may affect genes at the molecular level as well as physiological functions. Understanding the cellular responses during starvation is necessary for developing strategies to reduce damage caused by starvation stress. After 1 h of starvation, Got1 gene expression was increased but its expression returned to the normal state after 24 h. Mat1 gene expression continuously increased with starvation from 1 h until 24 hr. Rats starved for 1-3 days showed significant changes in expression of the Got1 and Mat1 genes, which were significantly reduced in the cerebral cortex and cerebellum. In the lung, gene expression was increased by starvation for 1-2 days but decreased on the third day. No differences were observed in gene expression in the heart. Strong Got1 lung gene expression was seen in the starvation group one day after restoration of the food supply. Muscle mass was significantly reduced at the start of starvation and remained the same after two days of starvation and one day after the food supply was restored. The Mat1 gene expression did not change. The Got1 was induced by NaCl and showed strong expression in the lung and the thymus, but the apparent decrease of the remaining changes were not observed in male rats. The Mat1 gene was not as sensitive as the Got1 gene to induction by NaCl. However, differences in gene induction by NaCl were evident between males and females, indicating that diet control of gene expression is associated with hormones.
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KEYWORD
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Glutamic oxaloacetic transaminase I (Got1), Methionine adenosyltransferase I (Mat1), starvation stress
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